Biomarkers in periodontitis
WebMar 30, 2024 · Recent paper reviews and meta-analyses have focused on five promising host derived biomarkers as candidate for early diagnosis of periodontitis: MMP-8 (Metalloproteinase-8), MIP-1α (Macrophage inflammatory protein-1 alpha), IL-1 β (Interleukin-1 beta), IL-6 (Interleukin-6), and HB (Hemoglobin), and their combinations. WebJan 14, 2024 · Recently, salivary levels of IL-1ß and hepatocyte growth factor (HGF) were reported to be the most robust biomarkers for periodontal diseases [ 18 ]. HGF is produced by periodontal ligament cells and fibroblasts and enhances production of MMPs and may drive apical migration of epithelial cells in periodontitis.
Biomarkers in periodontitis
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WebJan 25, 2024 · An interesting group of biomarkers that merit further investigation are the polyamines. Polyamines are a group of molecules consisting of cadaverine, putrescine, spermine and spermidine and have been implicated in the development of a range of systemic diseases, in part due to their production in periodontitis. WebApr 8, 2024 · Longitudinal studies have found high levels of biomarkers, such as matrix metalloproteinase-8 (MMP-8), MMP-9 and IL-1β in patients with high sensitivity and …
WebSep 28, 2024 · Thus MMP-8 is currently considered to be one of the most promising biomarkers for periodontitis in oral fluids. [13] While some studies showed higher levels of salivary MMP-8 in periodontitis patients compared with healthy individuals, [14,15] other studies showed opposite or contradictory results. [16,17] To the best of our knowledge, … WebNov 9, 2024 · Periodontitis is a complex multifactorial disease that can lead to destruction of tooth supporting tissues and subsequent tooth loss. The most recent global burden of …
WebDec 10, 2024 · In part I of this study, we focus on biomarkers from blood serum in patients with periodontitis, before surgical therapy and under a healing period 12 months. In part II, biomarkers in the locally collected GCF will be analyzed together with clinically reported measurements and compared with biomarkers in blood serum. Hypothesis are. WebOct 12, 2015 · Several inflammatory biomarkers found in blood or saliva have been studied for their potential to be utilized for monitoring the response to periodontal treatment; serum hsCRP, IL-6, oncostatin M, MMP-8 and MMP-9, and salivary sCD44, arginase, AST, ALT, LDH, sRANKL, and OPG have been identified as those with the greatest potential.
WebJan 1, 2024 · One of the main challenges in the field of periodontology is to discover an ideal periodontal diagnostic/prognostic biomarker, which would be able to achieve the …
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